Mercedes-Benz S-Class Sedan (W221) · S-Class
W221
Presence restored — the S-Class regains its authority.
- Production
- 2005–2013
- Built
- 547,599
- Body
- Sedan
- Chassis
- W221

The W221 answered the criticism levelled at its predecessor by putting the muscle back — pronounced rear haunches, a deeper grille and a cabin that made the W220 look tentative.
Introduced in August 2005, it offered the M272 V6, M273 V8 and M275 V12, later joined by the M278 biturbo V8 and, from AMG, the naturally aspirated M156 6.2 and the M157 5.5 biturbo. It was the first Mercedes-Benz with Night View Assist, and the S 400 HYBRID of 2009 was the world’s first production car to use a lithium-ion battery.
A comprehensive 2009 facelift carried it through to June 2013, alongside long-wheelbase, Pullman and Guard derivatives built at Sindelfingen.

Every model.
11 model designations across 2005–2013 — engines, transmissions and series codes for the W221.
| Modelo | Anos-modelo | Chassis | Motor | Transmissão | Total |
|---|---|---|---|---|---|
| S 350 | 2005–2013 | 221 | M 272 / M 276 | 7G-TRONIC | — |
| S 450 | 2005–2013 | 221 | M 273 | 7G-TRONIC | — |
| S 500 | 2005–2013 | 221 | M 273 / M 278 | 7G-TRONIC | — |
| S 600 | 2005–2013 | 221 | M 275 | 5G-TRONIC | — |
| S 250 CDI | 2010–2013 | 221 | OM 651 | 7G-TRONIC | — |
| S 320 CDI | 2005–2013 | 221 | OM 642 | 7G-TRONIC | — |
| S 350 BlueTEC | 2009–2013 | 221 | OM 642 | 7G-TRONIC | — |
| S 420 CDI | 2005–2013 | 221 | OM 629 | 7G-TRONIC | — |
| S 400 HYBRID | 2009–2013 | 221 | M 272 + electric | 7G-TRONIC | — |
| S 63 AMG | 2005–2013 | 221 | M 156 / M 157 | AMG SPEEDSHIFT MCT 9G | — |
| S 65 AMG | 2005–2013 | 221 | M 275 | 5G-TRONIC | — |

